How do Nanoparticles Kill Viruses?
How Viruses Work
Viruses pose a threat to human health because of their incredible ability to evolve strategies to escape antiviral measures and to switch from their current host to a new host. SARS-CoV2 is one such novel coronavirus that is identified as the cause of ongoing coronavirus disease 2019 (COVID-19). In the current situation, the development of new vaccines for such viruses seems likely to continue to be elusive. Together with the prevailing risk to the health of millions of people, there is a grave need for antiviral compounds with a wide margin of effectiveness.
Complex interactions between the virus and the host cellular system orchestrate the course and severity of viral infections. These biological interactions involve the coordinated binding of multiple copies of complementing protein structures that are found on the surfaces of the virus and the host cells. This interplay between the two entities results in enhanced efficiency, specificity, and strengths of such interactions that enable the microbial agent to hijack the host for its survival. Due to the outbreak of the current infectious disease, COVID-19, pharmaceutical firms, and numerous researchers are seeking new antiviral agents. In the meantime, we have to protect ourselves by boosting our immune systems with the elements and tools we have available to us.
Why Use a Metal and How Silvercillin is Different
Metals have been used to kill microorganisms for ages. Silver is the most extensively studied metal for fighting infections and known for its curative properties. The use of silver ions was considered the standard care in many countries until the end of the 20th century. The microorganisms develop resistance against silver because this element attacks a broad range of microbes. However, one of the challenges has been to make silver accessible for assimilation by the body. If silver is not processed correctly, then it can lead to its build up in the body’s tissue and result in bluish-gray discoloration of large areas of skin, a condition called argyria. People have developed argyria from using homemade and commercial colloidal silver products.
As a solution, nanoscale materials have emerged as novel “antimicrobial agents” due to their unique physical and chemical properties. The advantage of using silver nanoparticles for permeation is that there is a continuous release of silver ions, enhancing its antimicrobial efficacy. These nanoparticles are smaller than 100 nanometers and have a high quantity of surface structures that permit them to bond with a variety of cells, which makes the cells unrecognizable by the floating virus. Consequently, the virus does not find a suitable surface to attach itself and penetrate the cell, neutralizing it.
The biological response of silver nanoparticles depends on crucial factors including their size, shape, particle morphology, surface chemistry, particle composition, ability to bind with each other, the rate at which it dissolves in the body, particle reactivity in solution, and efficiency of release of silver ions. The physicochemical properties of silver nanoparticles can either enhance the bioavailability of therapeutic agents or on the contrary, can affect cellular uptake, biological distribution, and consequent therapeutic effects. Therefore, the development of silver nanoparticles with controlled parameters that are uniform in size, morphology, and functionality are vital for various biomedical applications.
Silvercillin™ is a highly effective antimicrobial with silver nanoparticles and is composed of pure silver complexed with purified water. Silvercillin™ utilizes a technological breakthrough that allows the production of a silver particle small enough to enter a single red blood cell, enabling the silver to travel through capillaries, the tiniest blood vessels in the body, and inactivate viruses at the cellular level. Silvercillin™ is a superior silver which is exquisitely distinct from traditional colloidal (ionic) silvers due to many important chemical, physical and vibrational differences separating it far beyond other forms available. The main mechanism of colloidal silver involves chemical action, requiring direct contact with microbes, where each colloidal silver molecule can only kill one bacteria, whereas Silvercillin™ works in more than one way. Silvercillin™ technology can inactivate viruses at the DNA/RNA level. Incomplete segments of DNA/RNA are found in viruses and carry a slight magnetic charge. The silver in Silvercillin™ acts like a magnet, attracting these charged particles and binding the DNA so tightly that it inactivates the virus and prevents virus replication. This same mechanism of action does not take place with healthy cells, as their thicker, more protected cell membranes carry a balanced charge, which protects them from the silver’s magnetic attraction. Another mode of action is catalytic action which is far more effective than chemical action (how colloidal silver works) and allows Silvercillin™ to eradicate thousands of times more microbial agents including viruses than colloidal or ionic silver, allowing it to be much more effective at much lower, safer concentrations. While no other liquid silver antimicrobial product had received a patent for over 80 years, a US patent was issued in 2006 for this silver composition.
How Safe is Silvercillin, and Can I Use it With Medications (Hint: It may make your medication work even better!)?
Silvercillin™ is a broad-spectrum antimicrobial, anti-inflammatory (as inflammation is often caused by bacteria, virus, or mold), non-toxic, even if used multiple times per day for weeks, has no known side effects or contraindications and is safe for all individuals. It does not encourage microbial resistant strains, immune system support, and does not interfere with antibiotics. Silvercillin™ is not only safe to take with antibiotics but can work synergistically to increase the effectiveness of specific antibiotics. Silvercillin™ will help to “mop up” the resistant pathogens that the antibiotic may have left behind. Supporting this fact, a 2006 study published in Current Science looked at 19 common antibiotics in combination with a silver solution against seven different microbial organisms. The results of this study showed the increased efficacy of some antibiotics up to 10-fold, as the antibiotic-silver combination allowed for more complete clearing of the pathological organism. In sheer contrast, various studies have confirmed that colloidal silver can cause poor absorption of some drugs like thyroxine (used to treat thyroid deficiency) and interfere with certain antibiotics. Moreover, in 1999, the FDA also warned that colloidal silver is unsafe and ineffective for treating any disease or condition.
Silvercillin™ uses technology that permanently distributes the mineral into the structure of the water, so it will not fall out of solution or suspension which is in stark contrast to the properties of colloidal silver products. Colloidal silver is simply a suspension of tiny silver flakes in liquid. Particles in this suspension, while too small to be seen, are large enough to settle to the bottom over time. Here, the silver components can fall out of solution, causing them to aggregate in such areas as the blood, fat, and the brain. As a result, argyria (blue man syndrome, where silver aggregates in the body) has only been seen in cases of colloidal silver use after extended high dosing. Not surprisingly, colloidal silver suspensions contain up to 300,000 ppm of silver compared to Silvercillin™ which is effective at a much lower dosage of only 5–30 ppm. 99 percent of the silver leaves the body in twenty-four hours and all is cleared by 48 hours. This occurs because the silver in Silvercillin™ has been structured into the water, allowing the water molecule to get absorbed into the bloodstream and pass through circulation. It ultimately gets excreted unchanged, which means no toxic residues are formed. As a result, the pure silver in Silvercillin™ has been shown to provide a whole host of health benefits, from killing drug- resistant bacterial strains to inhibiting viral replication as well as stimulating stem cell production. It can be safely used both orally and topically with no known side effects.
Amazing Research That Sheds Light on its Potential
A study on humans with the AIDS virus demonstrates Silvercillin’s safety and beneficial properties in those who are immuno-compromised. The subjects were given silver using the same technology as in Silvercillin™ at six times the recommended dose for four months. Results showed that their immune system became stronger as well as normal or close-to-normal body weights were restored. Since Silvercillin™ is water-soluble, it is unable to penetrate fats. In turn, it cannot harm good bacteria such as lactobacillus, which includes a milk-like fat surrounding the bacteria. This difference sets them apart from most other bacteria molecules. Healthy cells in the body also contain a protective membrane (unlike the thin cell walls of microbial agents) with a balanced charge, making them well protected from the silver’s toxic effects. The active ingredient in Silvercillin™ has been shown to inhibit and/or kill an extensive array of harmful bacteria including MRSA (methicillin-resistant Staphylococcus aureus), which can be deadly. A Brigham Young University report found this silver to be effective at killing every pathogenic bacterium it was tested against at less than 10 ppm. Among this list were salmonella and E. coli (food poisoning), Klebsiella pneumonia and oxytoca (pneumonia), Haemophilus influenza (ear infections, meningitis), Enterobacter aerogenes (UTIs), and Streptococcus mutans and gordonii (tooth decay). Fungal infections are often refractory which can make them drug-resistant and difficult to treat. Numerous studies show that Silvercillin’s lethal properties are also evident against mold, fungi, and yeast, making it an excellent choice for use against Candida albicans. A study revealed that silver was effective at inhibiting the growth of and killing Candida albicans at a dose of 10 ppm after only two hours of exposure. Also, consider using Silvercillin™ in the oral cavity to prevent fungal infections (Candida- thrush) and oral plaque build-up.
In the crusade toward drug production for viral disease treatment, the emergence of resistant viral strains and adverse side effects associated with extended use pose significant challenges that are difficult to avoid. Hence, multidisciplinary research activities, which are combined with traditional epidemiology and clinical methods, are also essential to the production of enhanced antivirals by an alternative strategy. Nanotechnology has emerged to re-examine the biological properties of proven antimicrobial substances, such as metals, by manipulating their sizes. Metal nanoparticles have been shown to exhibit virucidal activity against a broad spectrum of viruses, particularly those generated with silver or gold, and certainly to that viral infectivity of cultivated cells. In most cases, a direct association could be demonstrated or inferred between the nanoparticles and the surface proteins of the viruses. In the wake of COVID-19 being declared pandemic, we believe that Silvercillin™, owing to its antiviral properties and mode of action, can be a ray of hope for fighting against the novel coronavirus SARS-CoV2.
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