Heat Sensitive Product: Click here for our related policy.
Heat Sensitive Shipping Policy
Designs for Health has certain items that are sensitive to higher temperatures and higher humidity levels, and therefore may require shipping in a cool environment depending on your location and time of year. For example, we recommend that probiotics ship year-round with a cooler bag and cold packs. Cold packs may melt during shipping which should not affect product integrity, as they take a long time to melt, and because probiotics are manufactured with overages that ensure label potency when exposed to higher temperatures.
It is also recommended that PaleoBars? and all softgel products ship with a cooler bag and cold packs if the temperatures are expected to exceed 80?F for a prolonged period of time during transit. These items are subject to special shipping procedures due to their sensitive nature. In order to maintain this policy, our customer service department monitors the weather and transit time daily.
We endeavor to deliver all orders, including heat-sensitive items, within one to three business days. Expedited and guaranteed shipping services are available at an additional cost. Depending on the day of order and ship-to address, we may not be able to ship heat-sensitive orders until the following Monday to avoid orders held in transit over the weekend. For orders that combine heat-sensitive and non-heat-sensitive items, customers may elect to have their order ship in its entirety on Monday, or choose to split their order and have only their heat-sensitive products ship on Monday. If the customer elects to split their order, Designs for Health?s regular shipping policies will apply to each shipment?s value.
At our discretion, Designs for Health will add a cooler bag (s) to your order to ensure product potency and integrity.
For any questions regarding our Heat-Sensitive Policy, please contact Customer Service at 1.800.847.8302.
What actions does DIM have on the body that make it beneficial to our health?
Research tells us that a low level of the 2-hydroxyestrone and a high level of 16 alpha-hydroxyestrone is associated with an enhanced risk of breast cancer. DIM increases 2-hydroxyestrone and therefore improves the 2/16 hydroxyestrone ratio, making it very protective for women and men at high risk for this condition. Research by Bradlow has shown that DIM also reduces availability of 4-androstenedione for aromatization to estrone, a more dangerous form of estrogen. He concludes that DIM is more potent than I3C at protecting against breast cancer due to decreased formation of 16 alpha-hydroxyestrone from estrone.
DIM supplementation improves the estrogen ratio in a favorable direction that protects both men and women without the negative effect of raising 4 hydroxyestrogen as seen with I3C. DIM does not block ovulation the way I3C does, and can be used safely along with Tamoxifen, unlike I3C.
DIM should be considered first line therapy for hormone imbalances that can lead to negative conditions such as PMS, PCOS, endometriosis, fibroid tumors, menopausal symptoms, weight problems and the list goes on.
Recent research is positive so far that DIM improves weight loss resistance due to hormonal imbalance.
Is DIM hard to absorb?
Due to its crystalline structure, absorption of DIM when given orally simply as a powder in a capsule is minimal, similar to CoQ10. DIM absorption can be greatly enhanced by emulsifying it with lecithin in rice bran oil, including with it compounds that hold it in solution such as beeswax, and finally adding fat-soluble nutrients that aid absorption through the gut wall. DIM-Avail is a unique combination of such ingredients. DIM-Avail uses the same proven technology of Designs for Health?s Q-Avail, recently shown in human subjects to have far superior bioavailability and peak absorption rates in comparison to powdered CoQ10 and sublingual forms.
Patients should expect to get therapeutic results taking DIM-Avail at the recommended dose of 1softgel per day, taken with a meal.