Lithium Synergy™ combines lithium orotate, known for its ability to help stabilize mood swings related to depression and other mood disorders, with vitamin B12 (methylcobalamin) and trimethylglycine to support healthy methylation pathways.
How does lithium orotate work?
Mood disorders are often due to inositol depletion. Lithium recycles and synthesizes inositol by inhibiting IMPase enzyme. The phosphoinositol signaling pathway is involved in cell membrane signaling cascades. When salts of lithium are ingested, the lithium ions interact with several neurotransmitters and receptors in the central nervous system resulting in decreased norepinephrine release and increased serotonin synthesis.
Why add vitamin B12 and TMG (trimethylglycine)?
Vitamin B12 in the form of methylcobalamin and trimethylglycine both can donate methyl groups to improve methylation, often a weakness in patients with depression and other disorders.
Observational studies have found as many as 30% of patients hospitalized for depression are deficient in vitamin B12. The reasons for the relationship between vitamin B12 deficiency and depression may involve s-adenosylmethionine (SAMe). Vitamin B12 is required for the synthesis of SAMe, a methyl group donor essential for methylation reactions and subsequently the metabolism of neurotransmitters. SAMe deficiency has been related to depression. This hypothesis is supported by several studies that have shown supplementation with SAMe improves depressive symptoms.